If you’ve never enjoyed a meal at Mary Jane Burgers & Brew at 102 N. Jackson St. in Perryville, it might be time to make that a priority. In a region dotted with lunch and dinner spots, Mary Jane Burgers & Brew has carved out a reputation for its mix of solid food, friendly atmosphere, and clever concept.
Began as a dream
According to the restaurant’s website, Mary Jane Burgers & Brew started as a dream to bring something fun, fresh, and community- oriented to downtown Perryville. Owner Carisa Stark wanted a place where people could not only get a great burger, but linger — grab a brew, chat with friends, enjoy music, soak in a comfortable vibe. Over time, the concept has evolved, but that core idea remains — eat, drink & be Mary.
Located in a repurposed building in the heart of downtown, Mary Jane Burgers & Brew doesn’t just sell burgers — it sells a sense of place. Its interior design nods to local charm, with touches that invite you to stay a while (rather than rush through). Online reviewers often mention that the building itself adds character to the experience.
What customers say
Reviews are mostly glowing. On Restaurant Guru, one guest praised the “repurposed building” as “a perfect setting for the restaurant.” Yelp reviewers call it “super solid BBQ and sides” with “friendly service, cute decor.” People frequently mention that, while Mary Jane Burgers & Brew can get busy (especially during peak hours), the wait is worth it for quality food and a lively atmosphere.
One fun side note: the place is pet-friendly. According to BringFido, there are a few tables on the front patio where you can bring your dog along while you dine.
Standout offerings
Mary Jane Burgers & Brew’s menu is broad and designed to please — burgers, sandwiches, salads, shareables, wings, rice bowls, tacos, and rotating craft brews top the list. They also host special events; for instance, the restaurant is hosting a Fall Beer Pairing Dinner at 6 p.m. Thursday, Nov. 6, featuring a special four-course menu paired with craft beers from Piney River Brewing. Advanced reservations are required.
Why it works
These dinners offer curated multi-course meals paired with craft beers — a fun way for regulars and newcomers alike to explore flavors beyond the standard menu. What makes Mary Jane Burgers & Brew more than just “another burger spot” is how it leans into being a destination rather than a stop. The owners have made it a place where people meet, linger, celebrate — and trust the food will deliver. With solid reviews, a loyal following, and events that keep people coming back, Mary Jane Burgers & Brew stands out in southeast Missouri’s dining scene.
If you’re planning a night out (or even just a casual lunch), Mary Jane Burgers & Brew offers something rare: good food, a comfortable space, and vibes that say, “you belong here.” It’s no wonder so many Perryville residents count it among their favorites — and for folks passing through, it’s a shining example of why small-town Missouri dining still has plenty of surprises up its sleeve.
Dining hours are Monday-Thursday: 11 a.m. to 9 p.m.; Friday: 11 a.m. to 10 p.m;; Saturday: 10 a.m. to 10 p.m.; and Sunday: 10 a.m. to 8 p.m. Note: Brunch is served every Saturday and Sunday from 10 a.m. to 2 p.m. The bar is open until the last guest leaves. For an online look at the restaurant’s eclectic menu, go to its website at maryjaneburgers.com. To contact the restaurant by phone, call 573-547-6279.
